Control of brain metastasis in metastatic or recurrent breast cancer is a major theme for cancer treatment. Promising targeted therapy for epidermal growth factor receptor EGFR gene mutation-positive lung adenocarcinoma is effective systemic treatment also for brain metastasis. On the other hand, standard treatment for BCBMs is still local treatment for brain.
Longer survival of patients with metastatic breast cancer and the use of better imaging techniques are associated with an increased incidence of brain metastases. Unfortunately, patients who develop brain metastases tend to have poor prognosis with short overall survival. In addition, brain metastases are a major cause of morbidity, associated with progressive neurologic deficits that result in a reduced quality of life.
Brain metastases are the most common central nervous system tumors in adults, and incidence of brain metastases is increasing due to both improved diagnostic techniques e. Outcomes of patients remain disappointing and treatment options are limited, usually involving multimodality approaches. Brain metastases represent an unmet medical need in solid tumor care, especially in breast cancer, where brain metastases are frequent and result in impaired quality of life and death.
Brain metastasis is cancer that started in another part of the body and spread to the brain. Brain metastasis is not the same as cancer that starts in the brain called primary brain cancer. Brain metastases are much more common than primary brain cancer. Some kinds of cancer are more likely to spread to the brain than others.
Skip to Content. Use the menu to see other pages. This section explains the types of treatments that are the standard of care for metastatic breast cancer.
What is secondary breast cancer in the brain? Newly diagnosed or worried about a symptom? What is leptomeningeal metastases?
For most, the breast cancer has already traveled to another part of the body, such as the bones, liver, or lung. The risk of cancer spread to the brain is usually highest for women with more aggressive subtypes of breast cancer, such as HER2-positive or triple-negative breast cancer. If your doctor suspects brain metastasis, he or she will order an MRI magnetic resonance imaging study of the brain, often with contrast solution.
Breast cancer brain metastases: new directions in systemic therapy. Nancy U Lin. Correspondence to: Nancy U Lin.
This shows tumors that developed after cancer from a tumor elsewhere in the body spread metastasized to the brain. Brain metastases occur when cancer cells spread from their original site to the brain. Any cancer can spread to the brain, but the types most likely to cause brain metastases are lung, breast, colon, kidney and melanoma. Brain metastases, or secondary brain tumors, occur in 10 to 30 percent of adults with cancer.